FR901277, A NOVEL INHIBITOR OF HUMAN-LEUKOCYTE ELASTASE FROM STREPTOMYCES-RESISTOMYCIFICUS - PRODUCING ORGANISM, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

被引：13

作者：

FUJIE, K ^{[1
]}

SHINGUH, Y ^{[1
]}

HATANAKA, H ^{[1
]}

SHIGEMATSU, N ^{[1
]}

MURAI, H ^{[1
]}

FUJITA, T ^{[1
]}

YAMASHITA, M ^{[1
]}

OKAMOTO, M ^{[1
]}

OKUHARA, M ^{[1
]}

机构：

[1] FUJISAWA PHARMACEUT CO LTD,EXPLORAT RES LABS,5-2-3 TOKODAI,TSUKUBA,IBARAKI 30026,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 06期

关键词：

D O I：

10.7164/antibiotics.46.908

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel human leukocyte elastase inhibitor, FR901277 was discovered in the fermentation broth of Streptomyces resistomycificus No. 7622. FR901277 has a molecular weight of 961 and a molecular formula of C47H63N9O13. The mode of inhibition is competitive, with a Ki of 1.2 x 10(-8) M. Oral administration of FR901277 at doses from 32 to 320 mg/kg significantly prevented human leukocyte elastase-induced foot edema in mice.

引用

页码：908 / 913

页数：6

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