DETECTION OF MHC CLASS-II ANTIGENS ON MACROPHAGES AND MICROGLIA, BUT NOT ON ASTROCYTES AND ENDOTHELIA IN ACTIVE MULTIPLE-SCLEROSIS LESIONS

被引:222
|
作者
BO, L
MORK, S
KONG, PA
NYLAND, H
PARDO, CA
TRAPP, BD
机构
[1] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205
[2] UNIV BERGEN,HAUKELAND HOSP,DEPT PATHOL,N-5021 BERGEN,NORWAY
[3] UNIV BERGEN,HAUKELAND HOSP,DEPT NEUROL,N-5021 BERGEN,NORWAY
[4] JOHNS HOPKINS UNIV,SCH MED,DEPT PATHOL,BALTIMORE,MD 21205
关键词
MULTIPLE SCLEROSIS; MHC CLASS II; MACROPHAGE; MICROGLIA;
D O I
10.1016/0165-5728(94)90075-2
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Tissue sections of brains from patients with multiple sclerosis (MS) and from control individuals were immunostained with MHC class II and glial or vascular endothelial cell antibodies and analyzed by confocal microscopy. MHC class II was abundant in and around actively demyelinating MS lesions and was detected on microglia, phagocytic macrophages, and perivascular macrophages. Astrocytes and vascular endothelial cells were MHC class II-negative. Changes in the size and shape of MHC class II-positive cells associated with MS lesions suggest that microglia transform into phagocytic macrophages, and that they are actively involved in demyelination. Many MHC class II-positive perivascular macrophages within MS lesions contained abundant intracellular MHC class II immunoreactivity; these cells may be involved in antigen presentation and in T cell activation.
引用
收藏
页码:135 / 146
页数:12
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