NEWBORN PIGLET MODEL FOR CAMPYLOBACTERIOSIS

被引：72

作者：

BABAKHANI, FK ^{[1
]}

BRADLEY, GA ^{[1
]}

JOENS, LA ^{[1
]}

机构：

[1] UNIV ARIZONA,DEPT VET SCI,TUCSON,AZ 85721

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 08期

关键词：

D O I：

10.1128/IAI.61.8.3466-3475.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An in vivo model system for human campylobacteriosis has been developed in which colostrum-deprived newborn piglets are orally challenged with an invasive strain of Campylobacter jejuni. Piglets developed clinical symptoms and histopathological lesions similar to those observed in humans infected with C. jejuni. Gross lesion examination at autopsy revealed the presence of edema, hyperemia, and mucus. Histopathologic examinations by light and transmission electron microscopy demonstrated damage to surface epithelial cells with the presence of intracellular bacteria, mainly in the large intestine. Similar lesions were not demonstrated in control piglets.

引用

页码：3466 / 3475

页数：10

共 33 条

[1]

BELL JA, 1990, CAN J VET RES, V54, P432

[2] A DOMESTIC FERRET MODEL OF IMMUNITY TO CAMPYLOBACTER-JEJUNI-INDUCED ENTERIC DISEASE [J].