HIGH-SPEED DETERMINATION OF DRUG-RELATED IMPURITIES BY CAPILLARY ELECTROPHORESIS EMPLOYING COMMERCIAL INSTRUMENTATION

被引：38

作者：

ALTRIA, KD

机构：

[1] Pharmaceutical Analysis, Glaxo Group Research, Ware, Herts., Park Road

来源：

JOURNAL OF CHROMATOGRAPHY | 1993年 / 636卷 / 01期

关键词：

D O I：

10.1016/0021-9673(93)80064-F

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

High-speed capillary electrophoresis (HSCE) separations of pharmaceuticals are presented with high efficiency separations being achieved typically within 2 min. These results are obtained by applying high voltages across relatively short capillaries. Separation selectivity is shown to be similar to normal-speed CE. Quantitative HSCE impurity results compare well to those achieved by CE, TLC and HPLC. Analytical method validation criteria for HSCE such as linearity, precision and limits of detection are assessed.

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页码：125 / 132

页数：8

相关论文

共 26 条

[1] COMPARISON OF ISOTACHOPHORESIS, CAPILLARY ZONE ELECTROPHORESIS AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY FOR THE DETERMINATION OF SALBUTAMOL, TERBUTALINE SULFATE AND FENOTEROL HYDROBROMIDE IN PHARMACEUTICAL DOSAGE FORMS [J].

ACKERMANS, MT ;

BECKERS, JL ;

EVERAERTS, FM ;

SEELEN, IGJA .

JOURNAL OF CHROMATOGRAPHY, 1992, 590 (02) :341-353

[2] CHIRAL SEPARATION OF BETA-AMINO ALCOHOLS BY CAPILLARY ELECTROPHORESIS USING CYCLODEXTRINS AS BUFFER ADDITIVES .1. EFFECT OF VARYING OPERATING PARAMETERS [J].

ALTRIA, KD ;

GOODALL, DM ;

ROGAN, MM .

CHROMATOGRAPHIA, 1992, 34 (1-2) :19-24

[3] REDUCTIONS IN SAMPLE PRETREATMENT REQUIREMENTS BY USING HIGH-PERFORMANCE CAPILLARY ELECTROKINETIC SEPARATION METHODS [J].

ALTRIA, KD ;

ROGAN, MM .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1990, 8 (8-12) :1005-1008

[4] PHARMACEUTICAL ANALYSIS BY CAPILLARY ZONE ELECTROPHORESIS AND MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY [J].

ALTRIA, KD ;

SMITH, NW .

JOURNAL OF CHROMATOGRAPHY, 1991, 538 (02) :506-509

[5]

ALTRIA KD, IN PRESS J CHROMATOG

[6] CAPILLARY ELECTROPHORESIS OF PROTEINS IN BUFFERS CONTAINING HIGH-CONCENTRATIONS OF ZWITTERIONIC SALTS [J].

BUSHEY, MM ;

JORGENSON, JW .

JOURNAL OF CHROMATOGRAPHY, 1989, 480 :301-310

[7] RAPID PROTEIN-ANALYSIS BY CAPILLARY ELECTROPHORESIS [J].

CHEN, FTA .

JOURNAL OF CHROMATOGRAPHY, 1991, 559 (1-2) :445-453

[8] Z-SHAPED FLOW CELL FOR UV-DETECTION IN CAPILLARY ELECTROPHORESIS [J].

CHERVET, JP ;

VANSOEST, REJ ;

URSEM, M .

JOURNAL OF CHROMATOGRAPHY, 1991, 543 (02) :439-449

[9]

DESTY DH, 1965, ADV CHROMATOGR, V1, P100

[10] CHROMATOGRAPHIC METHODS FOR DETERMINING THE IDENTITY, STRENGTH AND PURITY OF RANITIDINE HYDROCHLORIDE BOTH IN THE DRUG SUBSTANCE AND ITS DOSAGE FORMS - AN EXERCISE IN METHOD SELECTION, DEVELOPMENT, DEFINITION AND VALIDATION [J].

EVANS, MB ;

HAYWOOD, PA ;

JOHNSON, D ;

MARTINSMITH, M ;

MUNRO, G ;

WAHLICH, JC .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1989, 7 (01) :1-&