EVIDENCE FOR OLIGOMANNOSYL RESIDUES CONTAINING BOTH BETA-1,2 AND ALPHA-1,2 LINKAGES AS A SEROTYPE-A-SPECIFIC EPITOPE(S) IN MANNANS OF CANDIDA-ALBICANS

被引：77

作者：

KOBAYASHI, H ^{[1
]}

SHIBATA, N ^{[1
]}

SUZUKI, S ^{[1
]}

机构：

[1] TOHOKU COLL PHARMACEUT SCI, DEPT HYG CHEM 2, 4-4-1 KOMATSUSHIMA, AOBA KU, MIYAGI 981, JAPAN

来源：

INFECTION AND IMMUNITY | 1992年 / 60卷 / 05期

关键词：

D O I：

10.1128/IAI.60.5.2106-2109.1992

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In order to identify the branches containing both beta-1,2 and alpha-1,2 linkages as the serotype A-specific epitope(s) in the mannans of Candida albicans, serotype A strains with oligosaccharides constituting the beta-1,2 linkage, the alpha-1,2 linkage, and both the beta-1,2 and the alpha-1,2 linkages were prepared from the mannans of C. albicans serotype A strains (NIH A-207 and J-1012) and tested for their inhibitory effects in the precipitin and slide agglutination assays. The results indicated that two oligosaccharides containing both beta-1,2 and alpha-1,2 linkages, Manp-beta-1-2Manp-alpha-1-2Manp-alpha-1-2Manp-alpha-1-2Man and Manp-beta-1-2Manp-beta-1-2Manp-alpha-1-2Manp-alpha-1-2Manp-alpha-1-2Man, served as epitopes participating in the serotype A specificity of C. albicans strains.

引用

页码：2106 / 2109

页数：4

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