ANAPLASTIC GANGLIOGLIOMA OF THE BRAIN-STEM DEMONSTRATING ACTIVE NEUROSECRETORY FEATURES OF NEOPLASTIC NEURONAL CELLS

被引：43

作者：

HIROSE, T ^{[1
]}

KANNUKI, S ^{[1
]}

NISHIDA, K ^{[1
]}

MATSUMOTO, K ^{[1
]}

SANO, T ^{[1
]}

HIZAWA, K ^{[1
]}

机构：

[1] UNIV TOKUSHIMA,SCH MED,DEPT NEUROSURG,TOKUSHIMA 770,JAPAN

来源：

ACTA NEUROPATHOLOGICA | 1992年 / 83卷 / 04期

关键词：

GANGLIOGLIOMA; GANGLION CELL TUMOR; BRAIN STEM; CHROMOGRANIN; DENSE-CORE GRANULE;

D O I：

10.1007/BF00713527

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

An autopsy case of anaplastic ganglioglioma in the brain stem of a 12-year-old girl is reported. The ill-defined tumor involVed the right cerebellar peduncle, medulla oblongata and upper cervical spinal cord, and showed mixed proliferation of many ganglioid cells and atypical pilocytic astrocytes with necrotic areas. Immunohistochemical studies revealed the presence of chromogranin A in most ganglioid cells and of metenkephalin in some large ganglioid cells. Glial cells were positive for glial fibrillary acidic protein and vimentin. Ultrastructurally, numerous dense-core granules of 90-220 nm in diameter were demonstrated in ganglioid cells and abundant glial filaments in glial cells. High neurosecretory activity in neuronal cells, suggested by chromogranin-immunoreactivity and dense-core granules, seems to be the most characteristic property of ganglion cell tumors.

引用

页码：365 / 370

页数：6

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