DEVELOPMENT OF A RAPID SCREENING ASSAY FOR PCDDS AND PCDFS

被引：12

作者：

BUNCE, NJ

LOGAN, R

SCHNEIDER, UA

机构：

[1] Department of Chemistry, Biochemistry University of Guelph, Guelph

来源：

CHEMOSPHERE | 1990年 / 20卷 / 10-12期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/0045-6535(90)90292-2

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

An assay for mixtures of PCDD-like compounds is being developed, based on the competitive binding of the mixture and a fixed aliquot of radiolabelled [3H]-TCDD towards the mouse hepatic Ah receptor protein. The results are expressed in terms of the concentration of unlabelled TCDD which produces the same response as the mixture. Preliminary experiments indicate that mixtures behave additively in this assay. © 1990.

引用

页码：1417 / 1422

页数：6

共 9 条

[1]

BRADFIELD CA, 1988, MOL PHARMACOL, V34, P682

[2] KINETIC-MODELS FOR ASSOCIATION OF 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN WITH THE AH RECEPTOR [J].