UCN-01 AND UCN-02, NEW SELECTIVE INHIBITORS OF PROTEIN KINASE-C .2. PURIFICATION, PHYSICOCHEMICAL PROPERTIES, STRUCTURAL DETERMINATION AND BIOLOGICAL-ACTIVITIES

被引：154

作者：

TAKAHASHI, I ^{[1
]}

SAITOH, Y ^{[1
]}

YOSHIDA, M ^{[1
]}

SANO, H ^{[1
]}

NAKANO, H ^{[1
]}

MORIMOTO, M ^{[1
]}

TAMAOKI, T ^{[1
]}

机构：

[1] KYOWA HAKKO KOGYO CO LTD,PHARMACEUT RES LABS,SHIZUOKA 411,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1989年 / 42卷 / 04期

关键词：

D O I：

10.7164/antibiotics.42.571

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

引用

页码：571 / 576

页数：6

共 6 条

[1] X-RAY CRYSTAL-STRUCTURE OF STAUROSPORINE - NEW ALKALOID FROM A STREPTOMYCES STRAIN [J].

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[2] STAUROSPORINE INHIBITS TYROSINE-SPECIFIC PROTEIN-KINASE ACTIVITY OF ROUS-SARCOMA VIRUS TRANSFORMING PROTEIN-P60 [J].

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[3] NEW ALKALOID AM-2282 OF STREPTOMYCES ORIGIN TAXONOMY, FERMENTATION, ISOLATION AND PRELIMINARY CHARACTERIZATION [J].

OMURA, S ;

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[4] UCN-01 AND UCN-02, NEW SELECTIVE INHIBITORS OF PROTEIN KINASE-C .1. SCREENING, PRODUCING ORGANISM AND FERMENTATION [J].

TAKAHASHI, I ;

ASANO, K ;

KAWAMOTO, I ;

TAMAOKI, T ;

NAKANO, H .

JOURNAL OF ANTIBIOTICS, 1989, 42 (04) :564-570

[5] UCN-01, A SELECTIVE INHIBITOR OF PROTEIN-KINASE-C FROM STREPTOMYCES [J].

TAKAHASHI, I ;

KOBAYASHI, E ;

ASANO, K ;

YOSHIDA, M ;

NAKANO, H .

JOURNAL OF ANTIBIOTICS, 1987, 40 (12) :1782-1784

[6] STAUROSPORINE, A POTENT INHIBITOR OF PHOSPHOLIPID/CA++DEPENDENT PROTEIN-KINASE [J].

TAMAOKI, T ;

NOMOTO, H ;

TAKAHASHI, I ;

KATO, Y ;

MORIMOTO, M ;

TOMITA, F .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 135 (02) :397-402

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