EFFECTS OF AMINO-BUTYLIDENE DIPHOSPHONATE IN HYPERCALCEMIA DUE TO MALIGNANCY

被引：26

作者：

BICKERSTAFF, DR ^{[1
]}

ODOHERTY, DP ^{[1
]}

MCCLOSKEY, EV ^{[1
]}

HAMDY, NAT ^{[1
]}

MIAN, M ^{[1
]}

KANIS, JA ^{[1
]}

机构：

[1] UNIV SHEFFIELD,SCH MED,DEPT HUMAN METAB & CLIN BIOCHEM,BEECH HILL RD,SHEFFIELD S10 2RX,S YORKSHIRE,ENGLAND

来源：

BONE | 1991年 / 12卷 / 01期

基金：

英国医学研究理事会;

关键词：

HYPERCALCEMIA OF MALIGNANCY; AMINOBUTYLIDENE DIPHOSPHONATE; BONE RESORPTION; RENAL TUBULAR REABSORPTION;

D O I：

10.1016/8756-3282(91)90049-O

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We studied the effect of a single 5 mg intravenous infusion of amino-butylidene diphosphonate (ABDP) in nine patients with hypercalcemia of malignancy, in whom serum calcium values were stable or rising after intravascular volume expansion. Serum calcium fell progressively in all patients and in seven reached the normal reference range by day 6 (p < 0.001). The decrease in serum calcium was associated with a decrease in the fasting urinary calcium/creatinine ratio (p < 0.05). Hypercalcemia recurred in seven of the patients by day 12, but two patients remained normocalcemic for 21 days. We conclude that ABDP is a highly potent diphosphonate and that a single intravenous infusion is capable of inhibiting tumour-mediated bone resorption for several days.

引用

页码：17 / 20

页数：4

共 26 条

[1]

ADAMI S, 1987, BONE MINER, V2, P395

[2]

ATKINS RM, 1987, J BONE MINER RES, V2, P273

[3] EFFECTS OF A NEW AMINODIPHOSPHONATE (AMINOHYDROXYBUTYLIDENE DIPHOSPHONATE) IN PATIENTS WITH OSTEOLYTIC LESIONS FROM METASTASES AND MYELOMATOSIS - COMPARISON WITH DICHLOROMETHYLENE DIPHOSPHONATE [J].

ATTARDOPARRINELLO, G ;

MERLINI, G ;

PAVESI, F ;

CREMA, F ;

FIORENTINI, ML ;

ASCARI, E .

ARCHIVES OF INTERNAL MEDICINE, 1987, 147 (09) :1629-1633

[4] BONE AND RENAL COMPONENTS IN HYPERCALCEMIA OF MALIGNANCY AND RESPONSES TO A SINGLE INFUSION OF CLODRONATE [J].

BONJOUR, JP ;

PHILIPPE, J ;

GUELPA, G ;

BISETTI, A ;

RIZZOLI, R ;

JUNG, A ;

ROSINI, S ;

KANIS, JA .

BONE, 1988, 9 (03) :123-130

[5]

BOONEKAMP PM, 1986, BONE MINER, V1, P27

[6] EFFECTS OF DISODIUM DICHLOROMETHYLENE DIPHOSPHONATE ON HYPERCALCEMIA PRODUCED BY BONE METASTASES [J].

CHAPUY, MC ;

MEUNIER, PJ ;

ALEXANDRE, CM .

JOURNAL OF CLINICAL INVESTIGATION, 1980, 65 (05) :1243-1247

[7] BIOCHEMICAL AND CLINICAL-RESPONSES TO DICHLOROMETHYLENE DIPHOSPHONATE (CL2MDP) IN PAGETS-DISEASE OF BONE [J].

DOUGLAS, DL ;

DUCKWORTH, T ;

KANIS, JA ;

PRESTON, C ;

BEARD, DJ ;

SMITH, TWD ;

UNDERWOOD, I ;

WOODHEAD, JS ;

RUSSELL, RGG .

ARTHRITIS AND RHEUMATISM, 1980, 23 (10) :1185-1192

[8]

FISKEN RA, 1980, Q J MED, V49, P405

[9]

FLEISCH H, 1989, RECENT RES CANCER, P1

[10]

FRIJLINK WB, 1979, LANCET, V1, P799

← 1 2 3 →