THE SPECIFICATION OF NEURONAL IDENTITY IN THE MAMMALIAN CEREBRAL-CORTEX

被引：24

作者：

MCCONNELL, SK

机构：

[1] Department of Biological Sciences, Stanford University, Stanford, 94305, California

来源：

EXPERIENTIA | 1990年 / 46卷 / 09期

关键词：

central nervous system; determination; lineage; migration; Neurogenesis;

D O I：

10.1007/BF01939385

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The determination of neuronal fate in the developing cerebral cortex has been studied by tracking normal cell lineages in the cortex, and by testing the commitment of young cortical neurons to their normal fates. These studies together suggest that neuronal progenitors are multipotent during development and have the potential to produce neurons destined for many or all of the cortical layers. However, the laminar identity of an individual neuron appears to be specified through environmental interactions at the time of the cell's temrinal mitotic division, prior to its migration into the cortical plate. © 1990 Birkhäuser Verlag Basel.

引用

页码：922 / 929

页数：8

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