Epidemiology and Characteristics of Metallo-beta-Lactamase-Producing Pseudomonas aeruginosa

被引：91
作者：
Hong, Duck Jin [1 ,2 ]
Bae, Il Kwon [3 ]
Jang, In-Ho [4 ]
Jeong, Seok Hoon [1 ,2 ]
Kang, Hyun-Kyung [3 ]
Lee, Kyungwon [1 ,2 ]
机构：
[1] Yonsei Univ, Coll Med, Dept Lab Med, 211 Eonju Ro, Seoul 135720, South Korea
[2] Yonsei Univ, Coll Med, Res Inst Bacterial Resistance, Seoul 135720, South Korea
[3] Silla Univ, Dept Dent Hyg, Busan, South Korea
[4] Sangji Univ, Coll Hlth Sci, Dept Biomed Lab Sci, Wonju, South Korea
来源：
INFECTION AND CHEMOTHERAPY | 2015年 / 47卷 / 02期
关键词：
Metallo-beta-lactamase; Pseudomonas aeruginosa; Carbapenem; Epidemiology; Multidrug resistance;
D O I：
10.3947/ic.2015.47.2.81
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Metallo-beta-lactamase-producing Pseudomonas aeruginosa (MPPA) is an important nosocomial pathogen that shows resistance to all beta-lactam antibiotics except monobactams. There are various types of metallo-beta-lactamases (MBLs) in carbapenem-resistant P. aeruginosa including Imipenemase (IMP), Verona integron-encoded metallo-beta-lactamase (VIM), Sao Paulo metallo-beta-lactamase (SPM), Germany imipenemase (GIM), New Delhi metallo-beta-lactamase (NDM), Florence imipenemase (FIM). Each MBL gene is located on specific genetic elements including integrons, transposons, plasmids, or on the chromosome, in which they carry genes encoding determinants of resistance to carbapenems and other antibiotics, conferring multidrug resistance to P. aeruginosa. In addition, these genetic elements are transferable to other Gram-negative species, increasing the antimicrobial resistance rate and complicating the treatment of infected patients. Therefore, it is essential to understand the epidemiology, resistance mechanism, and molecular characteristics of MPPA for infection control and prevention of a possible global health crisis. Here, we highlight the characteristics of MPPA.
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页码：81 / 97
页数：17
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