CATALYTIC AND STOICHIOMETRIC ENANTIOSELECTIVE ADDITION OF DIETHYLZINC TO ALDEHYDES USING A NOVEL CHIRAL SPIROTITANATE

被引：198

作者：

SCHMIDT, B

SEEBACH, D

机构：

[1] Laboratorium Für Organische Chemie, Eidgenössischen Technischen Hochschule, Eth-Zentrum, CH-8092

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1991年 / 30卷 / 01期

关键词：

D O I：

10.1002/anie.199100991

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Simple variation of the reaction conditions in the addition of Et2Zn to aldehydes in the presence of spirotitanate 1 can lead to a reversal in the configuration of the product. Stoichiometric amounts of the spirotitanate result in Re addition of Et2Zn to the aldehyde (up to 98% ee). In the presence of equimolar amounts of Ti(OCHMe2)4, catalytic amounts of 1 lead to Si addition of Et2Zn (up to 99% ee).

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页码：99 / 101

页数：3

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