STE11 IS A PROTEIN-KINASE REQUIRED FOR CELL-TYPE-SPECIFIC TRANSCRIPTION AND SIGNAL TRANSDUCTION IN YEAST

被引：157
作者：
RHODES, N
CONNELL, L
ERREDE, B
机构：
[1] UNIV N CAROLINA,DEPT CHEM,CHAPEL HILL,NC 27599
[2] UNIV N CAROLINA,GENET CURRICULUM,CHAPEL HILL,NC 27599
来源：
GENES & DEVELOPMENT | 1990年 / 4卷 / 11期
关键词：
Epitope-tagging; Gene expression; Protein kinase; Yeast mating response pathway;
D O I：
10.1101/gad.4.11.1862
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The STE11 gene of Saccharomyces cerevisiae is one of several genes requited for mating between two haploid cell types of this yeast. Its product is required for response to a signal that causes arrest of the mitotic cell cycle in the G1 phase and induction of mating-type-specific genes. The nucleotide sequence of the STE11 gene was determined. The predicted amino acid sequence shows homology to the protein kinase family. We demonstrate that the STE11 product has kinase catalytic activity and that this activity is required for its in vivo functions.
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页码：1862 / 1874
页数：13
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