NANOSCALE SELF-ASSEMBLY FOR DELIVERY OF THERAPEUTICS AND IMAGING AGENTS

被引：4

作者：

Chen, Mingnan ^{[1
]}

McDaniel, Jonathan R. ^{[1
]}

MacKay, J. Andrew ^{[2
]}

Chilkoti, Ashutosh ^{[1
]}

机构：

[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA

[2] Univ Southern Calif, Dept Pharmacol & Pharmaceut Sci, Los Angeles, CA 90033 USA

来源：

TECHNOLOGY AND INNOVATION | 2011年 / 13卷 / 01期

关键词：

Self-assembly; Vesicle; Micelle; Protein; Hydrogel; Inclusion complex;

D O I：

10.3727/194982411X13003853539948

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Self-assemblies are complex structures spontaneously organized from simpler subcomponents, primarily through noncovalent interactions. These structures are being exploited as delivery vehicles of therapeutic and imaging agents. They have two unique advantages in comparison to other vehicles: 1) they are able to assume complex structures that are difficult to attain by chemical synthesis, and 2) the dissociation of self-assembled structures can be triggered by external stimuli, which can serve as a mechanism of payload release. In this review, we discuss two naturally occurring (proteins and viral capsids) and five engineered self-assemblies (vesicles, micelles, proteins, hydrogels, and inclusion complexes) that are under development for delivery of drugs and imaging agents. For each class of self-assembled supramolecular structures, we examine its structural and physicochemical properties, and potential applications within the context of assembly, loading, and payload release.

引用

页码：5 / 25

页数：21

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