IMPORTANCE OF INTERLEUKIN-3 ON HISTAMINE-RELEASE FROM HUMAN BASOPHILS

被引：0

作者：

SUGIYAMA, H ^{[1
]}

EDA, R ^{[1
]}

HOPP, RJ ^{[1
]}

BEWTRA, AK ^{[1
]}

TOWNLEY, RG ^{[1
]}

机构：

[1] CREIGHTON UNIV,SCH MED,CTR ALLERG DIS,2500 CALIF ST,OMAHA,NE 68178

来源：

ANNALS OF ALLERGY | 1993年 / 71卷 / 04期

关键词：

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

We investigated the effects of interleukin-3 (IL-3) on histamine release (direct releasing and indirect enhancing effects) from basophils in allergic asthmatic subjects. Interleukin-3 caused direct histamine release (HR) in selected donors (IL-3 responders) and enhanced anti-IgE-induced HR in other IL-3 nonresponders, although both direct releasing and indirect enhancing activities of IL-3 on HR did not coexist with each other. There was a significant correlation between IL-3-induced HR and spontaneous histamine release (r = .8532, P < .0001).

引用

页码：391 / 395

页数：5

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