Treatment results of breast cancer patients with locoregional recurrence after mastectomy

被引：9

作者：

Jeong, Yuri ^{[1
]}

Kim, Su Ssan ^{[1
]}

Gong, Gyungyub ^{[2
]}

Lee, Hee Jin ^{[2
]}

Ahn, Sei Hyun ^{[3
]}

Son, Byung Ho ^{[3
]}

Lee, Jong Won ^{[3
]}

Choi, Eun Kyung ^{[1
]}

Lee, Sang-wook ^{[1
]}

Joo, Ji Hyeon ^{[1
]}

Do Ahn, Seung ^{[1
]}

机构：

[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Radiat Oncol, 88 Olympic Ro 43-Gil,Songpa Gu, Seoul 138736, South Korea

[2] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Seoul, South Korea

[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Surg, Seoul, South Korea

来源：

RADIATION ONCOLOGY JOURNAL | 2013年 / 31卷 / 03期

关键词：

Breast cancer; Locoregional recurrence; Mastectomy;

D O I：

10.3857/roj.2013.31.3.138

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: To analyze the results of locoregional and systemic therapy in the breast cancer patients with locoregional recurrence (LRR) after mastectomy. Materials and Methods: Seventy-one patients who received radiotherapy for isolated LRR after mastectomy between January 1999 and December 2009 were retrospectively reviewed. Among the 71 patients, 59 (83.1%) underwent wide excision and radiotherapy and 12 (16.9%) received radiotherapy alone. Adjuvant hormonal therapy was given to 45 patients (63.4%). Oncologic outcomes including locoregional recurrence-free survival, disease-free survival (DFS), and overall survival (OS) and prognostic factors were analyzed. Results: Median follow-up time was 49.2 months. Of the 71 patients, 5 (7%) experienced second isolated LRR, and 40 (56%) underwent distant metastasis (DM). The median DFS was 35.6 months, and the 3-and 5-year DFS were 49.1% and 28.6%, respectively. The median OS was 86.7 months, and the 5-year OS was 62.3%. Patients who received hormone therapy together showed better 5-year DFS and OS than the patients treated with locoregional therapy only (31.6% vs. 22.1%, p = 0.036; 66.5% vs. 55.2%, p = 0.022). In multivariate analysis, higher N stage at recurrence was a significant prognostic factor for DFS and OS. Disease free interval (= 30 months vs. > 30 months) from mastectomy to LRR was also significant for OS. The patients who received hormone therapy showed superior DFS and showed trend to better OS. Conclusion: DM was a major pattern of failure after the treatment of LRR after mastectomy. The role of systemic treatment for LRR after mastectomy should be investigated at prospective trials.

引用

页码：138 / 146

页数：9

共 25 条

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