SYNTHESIS OF 2-FLUORO-2-DEOXY-MYO-INOSITOL 1,4,5-TRISPHOSPHATE AND SCYLLO-INOSITOL 1,2,4-TRISPHOSPHATE, NOVEL ANALOGS OF THE 2ND MESSENGER MYOINOSITOL 1,4,5-TRISPHOSPHATE

被引：26
作者：
LAMPE, D
POTTER, BVL
机构：
[1] UNIV BATH,SCH PHARM & PHARMACOL,CLAVERTON DOWN,BATH BA2 7AY,AVON,ENGLAND
[2] UNIV BATH,INST LIFE SCI,BATH BA2 7AY,AVON,ENGLAND
来源：
TETRAHEDRON LETTERS | 1993年 / 34卷 / 14期
关键词：
D O I：
10.1016/S0040-4039(00)77615-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The novel myo-inositol 1,4,5-trisphosphate receptor agonists, 2-fluoro-2-deoxy-myo-inositol 1,4,5-trisphosphate and scyllo-inositol 1,2,4-trisphosphate, were synthesised in racemic form from suitably protected inositol precursors.
引用
收藏
页码：2365 / 2368
页数：4
相关论文
共 35 条
[21]  
MIGNERY GA, 1990, J BIOL CHEM, V265, P12679
[22]  
MOYER JD, 1988, MOL PHARMACOL, V33, P683
[23]   MOLECULAR RECOGNITION OF INOSITOL POLYPHOSPHATES BY INTRACELLULAR RECEPTORS AND METABOLIC ENZYMES [J].
NAHORSKI, SR ;
POTTER, BVL .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (04) :139-&
[24]   SYNTHESIS OF SOME DEOXY-FLUORO ANALOGS OF MYOINOSITOL [J].
OFFER, JL ;
METCALFE, JC ;
SMITH, GA .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1990, (19) :1312-1313
[25]   RECENT ADVANCES IN THE CHEMISTRY AND BIOCHEMISTRY OF INOSITOL PHOSPHATES OF BIOLOGICAL INTEREST [J].
POTTER, BVL .
NATURAL PRODUCT REPORTS, 1990, 7 (01) :1-24
[26]   SOLVENT EFFECTS IN BASE-CATALYZED ISOMERIZATION OF ALLYL TO PROPENYL ETHERS [J].
PRICE, CC ;
SNYDER, WH .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1961, 83 (07) :1773-&
[27]   SYNTHETIC D-ENANTIOMER AND L-ENANTIOMER OF 2,2-DIFLUORO-2-DEOXY-MYO-INOSITOL 1,4,5-TRISPHOSPHATE INTERACT DIFFERENTLY WITH MYOINOSITOL 1,4,5-TRISPHOSPHATE BINDING-PROTEINS - IDENTIFICATION OF A POTENT SMALL MOLECULE 3-KINASE INHIBITOR [J].
SAFRANY, ST ;
SAWYER, DA ;
NAHORSKI, SR ;
POTTER, BVL .
CHIRALITY, 1992, 4 (07) :415-422
[28]   CA-2+-MOBILIZING PROPERTIES OF SYNTHETIC FLUORO-ANALOGS OF MYOINOSITOL 1,4,5-TRISPHOSPHATE AND THEIR INTERACTION WITH MYOINOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE AND 5-PHOSPHATASE [J].
SAFRANY, ST ;
SAWYER, D ;
WOJCIKIEWICZ, RJH ;
NAHORSKI, SR ;
POTTER, BVL .
FEBS LETTERS, 1990, 276 (1-2) :91-94
[29]   3-POSITION MODIFICATION OF MYOINOSITOL 1,4,5-TRISPHOSPHATE - CONSEQUENCES FOR INTRACELLULAR CA2+ MOBILIZATION AND ENZYME RECOGNITION [J].
SAFRANY, ST ;
WILCOX, RA ;
LIU, CS ;
POTTER, BVL ;
NAHORSKI, SR .
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1992, 226 (03) :265-272
[30]   TOTAL SYNTHESIS OF FLUORINATED ANALOGS OF INOSITOL AND INOSITOL 1,4,5-TRISPHOSPHATE [J].
SAWYER, DA ;
POTTER, BVL .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1992, (07) :923-932
1234