CRYPTOPORIC ACIDS A-G, DRIMANE-TYPE SESQUITERPENOID ETHERS OF ISOCITRIC ACID FROM THE FUNGUS CRYPTOPORUS-VOLVATUS

被引：49

作者：

ASAKAWA, Y ^{[1
]}

HASHIMOTO, T ^{[1
]}

MIZUNO, Y ^{[1
]}

TORI, M ^{[1
]}

FUKAZAWA, Y ^{[1
]}

机构：

[1] HIROSHIMA UNIV,FAC SCI,DEPT CHEM,NAKA KU,HIROSHIMA 730,JAPAN

来源：

PHYTOCHEMISTRY | 1992年 / 31卷 / 02期

关键词：

CRYPTOPORUS-VOLVATUS; POLYPORACEAE; FUNGUS; DRIMANE-TYPE SESQUITERPENOID ETHERS; ISOCITORIC ACID; SUPEROXIDE ANION RADICAL RELEASE INHIBITOR; ANTITUMOR AND TUMOR PROMOTING ACTIVITY; PROTEIN KINASE-C ENHANCEMENT; PLANT GROWTH INHIBITORY ACTIVITY; BITTER PRINCIPLE;

D O I：

10.1016/0031-9422(92)90042-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven novel bitter drimane-type sesquiterpenoids with an isocitric acid group named cryptoporic acids (CA) A-G have been isolated from the fungus Cryptoporous volvatus and their absolute stereostructures established by a combination of chemical transformation, NMR spectral data and X-ray crystallographic analysis. Cryptoporic acids strongly inhibited the release of superoxide anion radicals from guinea-pig peritoneal macrophage as well as rabbit polymorphonuclear leucocyte. CA-E showed anti-tumour promoting activity whilst CA-D slightly enhanced tumour promoting and protein kinase C activity. CAs also inhibited elongation of the second coleoptile and germination of rice in husk at 200 ppm.

引用

页码：579 / 592

页数：14

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