ON THE USE OF S-TERT-BUTYLSULPHENYL GROUP FOR PROTECTION OF CYSTEINE IN SOLID-PHASE PEPTIDE-SYNTHESIS USING FMOC-AMINO ACIDS

The utilization of the N.alpha.-fluorenylmethoxycarbonyl derivative of S-t-butyl sulphenyl cysteine in solid-phase peptide synthesis for the preparation of several cysteine-containing peptides is described. When this derivative is located in the C-terminal position a side reaction prevents the formation of the desired product. Finally, a peptide containing a disulphide bond has been obtained in excellent yields by selective deprotection of the cysteines and disulfide bond formation on the solid transport.