ALLELIC VARIATIONS OF HUMAN TCR V-GENE PRODUCTS

被引：56
作者：
POSNETT, DN
机构：
[1] Division of Allergy and Immunology, Department of Medicine, Cornell University Medical College, New York
来源：
IMMUNOLOGY TODAY | 1990年 / 11卷 / 10期
关键词：
D O I：
10.1016/0167-5699(90)90143-W
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A central problem confronting the immune system is how to discriminate among vast numbers of antigens. Novel genetic ploys that aid the discriminative process, including complex gene rearrangements (in antibody and T-cell receptor (TCR) genes) and extensive allelic polymorphism (in major histocompatibility complex (MHC) genes), have been described. Recent evidence has suggested a further level of diversity. TCR V gene allelic variation. In this article David Posnett summarizes evidence in favour of this possibility and speculates on the possible functional consequences of TCR allelism. © 1990.
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收藏
页码：368 / 373
页数：6
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