CONCURRENT MUSCARINIC AND BETA-ADRENERGIC-BLOCKADE IN RATS IMPAIRS PLACE-LEARNING IN A WATER MAZE AND RETENTION OF INHIBITORY AVOIDANCE

被引:108
作者
DECKER, MW [1 ]
GILL, TM [1 ]
MCGAUGH, JL [1 ]
机构
[1] UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92717
关键词
Inhibitory avoidance; Muscarinic receptor; Neurotransmitter interaction; Propranolol; Rat; Scopolamine; Spatial learning; β-Adrenergic receptor;
D O I
10.1016/0006-8993(90)91091-T
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
These experiments examined the effects of separate and concurrent muscarinic cholinergic and β-adrenergic blockade on inhibitory (passive) avoidance performance and spatial learning in the Morris water maze. Pretraining systemic administration of either scopolamine (0.3 or 1.0 mg/kg) or propranolol (3.0 or 10.0 mg/kg) had no significant effect on one-day retention of step-through inhibitory avoidance training. Similarly, pretraining administration of either 0.3 mg/kg scopolamine or 10 mg/kg propanolol did not affect spatial learning in the Morris water maze. However, combined administration of scopolamine and 10.0 mg/kg of propranolol impaired performance on these tasks. These findings further support a role for interactions between norepinephrine and acetylcholine in the modulation of learning and memory and implicate the participation of β-adrenergic mechanisms in this interaction. Because cholinergic and noradrenergic deterioration is found in aging and Alzheimer's disease, these results also have implications regarding the role of age-related noradrenergic and cholinergic dysfunction in cognitive decline. © 1990.
引用
收藏
页码:81 / 85
页数:5
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