ISOENZYME STUDIES IN HUMAN-LEUKEMIA .1. ACID-PHOSPHATASE

被引：18
作者：
GAEDICKE, G
ARNDT, R
KABISCH, H
LANDBECK, G
机构：
[1] UNIV HAMBURG,KINDERKLIN,TUMORZENTRUM HAMBURG,BLUTGERINNUNGSFORSCH & ONKOL ABT,D-2000 HAMBURG 13,FED REP GER
[2] UNIV HAMBURG,MED KLIN 1,KLIN IMMUNOL ABT,D-2000 HAMBURG 13,FED REP GER
来源：
LEUKEMIA RESEARCH | 1979年 / 3卷 / 06期
关键词：
Acid phosphatase; childhood acute leukemia; common ALL subtyping; cytochemistry to ALL; isoenzymes;
D O I：
10.1016/0145-2126(79)90038-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Acid phosphatase (AcP) isoenzymes were investigated in acute lymphocytic leukemia (ALL), malignant Non-Hodgkin-lymphoma (NHL) and acute myelocytic leukemia (AML) by analytical isoelectric focusing in polyacrylamide gels (IEF). By this technique 5 groups of at least 8 isoenzymes were observed. A new subgroup of childhood common ALL (C-ALL) could be defined, lacking acid phosphatase activity by cytochemistry. However, IEF demonstrated the presence of the main isoenzyme band and the cells reacted positively with C-ALL antiserum. AcP isoenzymes of myelocytic and lymphocytic leukemic cells showed similar patterns in IEF. No leukemia specific isoenzyme could be demonstrated. The results indicate that childhood C-ALL cells may represent different differentiation stages. © 1980.
引用
收藏
页码：417 / 423
页数：7
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