NO INFLUENCE OF THE ANTIDEPRESSANT PAROXETINE ON CARBAMAZEPINE, VALPROATE AND PHENYTOIN

被引：62

作者：

ANDERSEN, BB

MIKKELSEN, M

VESTERAGER, A

DAM, M

KRISTENSEN, HB

PEDERSEN, B

LUND, J

MENGEL, H

机构：

[1] UNIV COPENHAGEN,HVIDOVRE HOSP,NEUROL CLIN 433,KETTEGAARD ALLE 30,DK-2650 HVIDOVRE,DENMARK

[2] AALBORG HOSP,DK-9000 AALBORG,DENMARK

[3] NOVO IND AS,DIV CNS,DK-2800 BAGSVAERD,DENMARK

来源：

EPILEPSY RESEARCH | 1991年 / 10卷 / 2-3期

关键词：

INTERACTIONS; ANTIDEPRESSIVE TREATMENT; PAROXETINE; CARBAMAZEPINE; VALPROATE; PHENYTOIN;

D O I：

10.1016/0920-1211(91)90013-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A single-blind, placebo-controlled, cross-over trial investigating possible interactions between paroxetine, a serotonin re-uptake inhibitor, and carbamazepine (CBZ), valproate (VPA) and phenytoin (PHT) was carried out in 20 outpatients with epilepsy. Patients on long-term treatment with CBZ, VPA, or PHT were given a 7-day placebo treatment, followed by paroxetin co-treatment for 16 days. Side effects were infrequent and mild. Paroxetine caused no changes in the plasma concentrations and all values were within the recommended ranges. No changes in protein binding were found. Plasma concentrations of paroxetine at steady state (8-147 ng/ml) were in the normal range for a 30-mg daily dosing regimen. None of the patients experienced epileptic seizures during the study.

引用

页码：201 / 204

页数：4

共 20 条

[1] DETERMINATION OF PAROXETINE IN HUMAN-PLASMA, USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH FLUORESCENCE DETECTION [J].