POSTTRANSCRIPTIONAL REGULATION OF TUBULIN MESSENGER-RNA IN DEVELOPING RAT-BRAIN

被引：5

作者：

BHATTACHARYA, B ^{[1
]}

SAHA, S ^{[1
]}

SARKAR, PK ^{[1
]}

机构：

[1] INDIAN INST CHEM BIOL,DEPT CELL BIOL,4 RAJA SC,MULLICK RD,CALCUTTA 700032,W BENGAL,INDIA

来源：

MOLECULAR BRAIN RESEARCH | 1991年 / 10卷 / 04期

关键词：

TUBULIN MESSENGER RNA; TRANSCRIPTION; POSTTRANSCRIPTIONAL MODULATION;

D O I：

10.1016/0169-328X(91)90094-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The transcriptional activity of tubulin genes during synaptogenesis in developing rat brain has been examined by 'nuclear run off assay'. For both alpha and beta-tubulin genes, the relative rates of transcription were found to be high during the early phase of synaptogenesis (postnatal days 1-5) and declined 20-50% by the end of synaptogenesis (postnatal days 15-20). Comparison of the developmental alterations in the rates of transcription of both alpha and beta-tubulin mRNA with the level of polysomal tubulin mRNA shows that the age related decline (70-80%) in the level of polysomal tubulin mRNA during synaptogenesis is much too large compared to the 20-25% decline in their transcription rates suggesting that tubulin mRNA levels in developing rat brain are regulated post-transcriptionally.

引用

页码：347 / 350

页数：4

共 17 条

[1] DEVELOPMENTAL CHANGES IN MICROTUBULE PROTEIN OF CHICK BRAIN [J].

BAMBURG, JR ;

SHOOTER, EM ;

WILSON, L .

BIOCHEMISTRY, 1973, 12 (08) :1476-1482

[2] MECHANISMS OF REGULATING TUBULIN SYNTHESIS IN CULTURED MAMMALIAN-CELLS [J].

BENZEEV, A ;

FARMER, SR ;

PENMAN, S .

CELL, 1979, 17 (02) :319-325

[3] REGULATION OF ALPHA-TUBULIN AND BETA-TUBULIN MESSENGER-RNAS IN RAT-BRAIN DURING SYNAPTOGENESIS [J].

BHATTACHARYA, B ;

MANDAL, C ;

BASU, S ;

SARKAR, PK .

MOLECULAR BRAIN RESEARCH, 1987, 2 (02) :159-162

[4] MODULATION OF TUBULIN SYNTHESIS BY TRI-IODOTHYRONINE IN THE EMBRYONIC CHICK BRAIN [J].

CHAUDHURY, S ;

CHAUDHURY, L ;

SARKAR, PK .

DEVELOPMENTAL BRAIN RESEARCH, 1983, 9 (03) :291-295

[5] STIMULATION OF TUBULIN SYNTHESIS BY THYROID-HORMONE IN THE DEVELOPING RAT-BRAIN [J].

CHAUDHURY, S ;

SARKAR, PK .

BIOCHIMICA ET BIOPHYSICA ACTA, 1983, 763 (02) :93-98

[6] INDUCTION OF BRAIN TUBULIN BY TRIIDOTHYRONINE - DUAL EFFECT OF THE HORMONE ON THE SYNTHESIS AND TURNOVER OF THE PROTEIN [J].

CHAUDHURY, S ;

CHATTERJEE, D ;

SARKAR, PK .

BRAIN RESEARCH, 1985, 339 (01) :191-194

[7] IS APPARENT AUTOREGULATORY CONTROL OF TUBULIN SYNTHESIS NONTRANSCRIPTIONALLY REGULATED [J].

CLEVELAND, DW ;

HAVERCROFT, JC .

JOURNAL OF CELL BIOLOGY, 1983, 97 (03) :919-924

[8] ELEVATION OF TUBULIN LEVELS BY MICROINJECTION SUPPRESSES NEW TUBULIN SYNTHESIS [J].

CLEVELAND, DW ;

PITTENGER, MF ;

FERAMISCO, JR .

NATURE, 1983, 305 (5936) :738-740

[9] UNPOLYMERIZED TUBULIN MODULATES THE LEVEL OF TUBULIN MESSENGER-RNAS [J].

CLEVELAND, DW ;

LOPATA, MA ;

SHERLINE, P ;

KIRSCHNER, MW .

CELL, 1981, 25 (02) :537-546

[10] NUMBER AND EVOLUTIONARY CONSERVATION OF ALPHA-TUBULIN AND BETA-TUBULIN AND CYTOPLASMIC BETA-ACTIN AND GAMMA-ACTIN GENES USING SPECIFIC CLONED CDNA PROBES [J].

CLEVELAND, DW ;

LOPATA, MA ;

MACDONALD, RJ ;

COWAN, NJ ;

RUTTER, WJ ;

KIRSCHNER, MW .

CELL, 1980, 20 (01) :95-105

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