REVERSIBILITY OF THE EFFECTS ON LOCAL CIRCULATION OF HIGH LIPID CONCENTRATIONS IN BLOOD

被引：46
作者：
BULOW, J
MADSEN, J
HOJGAARD, L
机构：
[1] UNIV COPENHAGEN,PANUM INST,INST MED PHYSIOL C,DK-2200 COPENHAGEN N,DENMARK
[2] UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT CLIN PHYSIOL NUCL MED,DK-2650 HVIDOVRE,DENMARK
来源：
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 1990年 / 50卷 / 03期
关键词：
Albumin; Free fatty acids; Lipid emulsion; Microspheres; Pig; Regional perfusion;
D O I：
10.3109/00365519009091581
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Regional perfusion and vascular resistance were examined in different tissues with the radioactive microsphere technique in Göttingen minipigs before, during and after treatment with Intralipid and heparin. This treatment led to an increase in the free fatty acid/albumin molar ratio from 0.39±0.23 to 3.43±1.37. Concomitantly a decrease in regional perfusion and an increase in regional vascular resistance was found in skin, adipose tissue, skeletal muscle, kidney, the gastro-intestinal tract, the thyroid and pancreas, while heart and liver showed vasodilatation. The vascular effects were fully reversible when the free fatty acid/albumin molar ratio had normalized. This vascular effect of lipid emulsions has to be considered when patients are treated with parenteral nutrition. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码：291 / 296
页数：6
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