SYSTEMIC AND RENAL FIBRINOLYTIC-ACTIVITY IN A PATIENT WITH ANTICARDIOLIPIN SYNDROME AND RENAL THROMBOTIC MICROANGIOPATHY

被引：36

作者：

BECQUEMONT, L ^{[1
]}

THERVET, E ^{[1
]}

RONDEAU, E ^{[1
]}

LACAVE, R ^{[1
]}

MOUGENOT, B ^{[1
]}

SRAER, JD ^{[1
]}

机构：

[1] HOP TENON,SERV NEPHROL,4 RUE CHINE,F-75970 PARIS 20,FRANCE

来源：

AMERICAN JOURNAL OF NEPHROLOGY | 1990年 / 10卷 / 03期

关键词：

D O I：

10.1159/000168093

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

A 24-year-old white woman with a past history of recurrent venous thromboses of the lower extremities was admitted for hypertension and renal failure. She had a chronic cutaneous ulcer on the anterior side of the left leg and oral ulcers of the palatum. Laboratory tests demonstrated rapidly progressive renal failure and the presence of an anticardiolipin antibody (ELISA). Thrombosis of the inferior vena cava was shown by phlebocavography. Renal biopsy revealed typical thrombotic microangiopathy. Tissue-type plasminogen activator (tPA) was visualized by immunofluorescence in endothelial cells of renal arterioles and glomeruli. Normal plasma levels of tPA, urokinase and plasminogen activator inhibitor 1 were found by ELISA, and tPA antigen levels rose after desmopressin acetate infusion. Thus, in this case, the diffuse thrombotic process was not related to defective circulating or renal fibrinolytic systems and could be promoted by the procoagulant effect of antiphospholipid antibodies.

引用

页码：254 / 258

页数：5

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