DISCRIMINATIVE STIMULUS PROPERTIES OF MORPHINE MEDIATED BY MU(1)-OPIOID RECEPTORS

被引：11

作者：

SUZUKI, T ^{[1
]}

MORI, T ^{[1
]}

TSUJI, M ^{[1
]}

MISAWA, M ^{[1
]}

NAGASE, H ^{[1
]}

机构：

[1] TORAY INDUSTRIES LTD,BASIC RES LABS,KAMAKURA,KANAGAWA 248,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 284卷 / 1-2期

关键词：

MORPHINE; DRUG DISCRIMINATION; MU(1)-OPIOID RECEPTOR;

D O I：

10.1016/0014-2999(95)00440-V

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The mu-opioid receptor subtypes involved in the discriminative stimulus properties of morphine were investigated in rats that had been trained to discriminate between 3.0 mg/kg morphine and saline. The discriminative stimulus properties of morphine were significantly attenuated by beta-funaltrexamine (an irreversible mu-opioid receptor antagonist: 10 and 20 mg/kg) and naloxonazine (an irreversible mu(1)-opioid receptor antagonist: 20 mg/kg). These results suggest that the discriminative stimulus properties of morphine may be mediated by mu(1)-opioid receptors.

引用

页码：195 / 198

页数：4

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