INTRAVENOUS CYCLOPHOSPHAMIDE PULSES IN THE TREATMENT OF PYODERMA-GANGRENOSUM ASSOCIATED WITH RHEUMATOID-ARTHRITIS - REPORT OF 2 CASES AND REVIEW OF THE LITERATURE

被引：0

作者：

ZONANANACACH, A ^{[1
]}

JIMENEZBALDERAS, FJ ^{[1
]}

MARTINEZOSUNA, P ^{[1
]}

MINTZ, G ^{[1
]}

机构：

[1] INST MEXICANO SEGURO SOCIAL,CTR MED NACL SIGLO 21,HOSP ESPECIALIDADES,DEPT REUMATOL,MEXICO CITY 06725,DF,MEXICO

来源：

JOURNAL OF RHEUMATOLOGY | 1994年 / 21卷 / 07期

关键词：

PYODERMA GANGRENOSUM; CYCLOPHOSPHAMIDE; RHEUMATOID ARTHRITIS; PULSE THERAPY;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pyoderma gangrenosum is a chronic ulceronecrotic inflammatory cutaneous disorder that can be associated with diseases such as rheumatoid arthritis (RA). No definitive treatment exists for this condition; steroids have been the mainstay of therapy, and the addition of immunosuppressives has been advocated. We describe 2 patients with pyoderma gangrenosum occurring in the setting of RA who, in addition to steroids, received pulse intravenous cyclophosphamide and had a remarkably good and lasting response. This is the first report of such a therapeutic approach. The pertinent literature is discussed. We conclude that pulse cyclophosphamide is another possible therapy for pyoderma gangrenosum.

引用

页码：1352 / 1356

页数：5

共 35 条

[1] RESOLUTION OF SEVERE PYODERMA-GANGRENOSUM IN A PATIENT WITH STREAKING LEUKOCYTE FACTOR DISEASE AFTER TREATMENT WITH TACROLIMUS (FK-506) [J].