QUALITATIVE AND QUANTITATIVE CHANGES IN UTERINE MESSENGER-RNA POPULATIONS IN RESPONSE TO ESTRADIOL TREATMENT OF RATS

被引：20
作者：
AZIZ, S [1 ]
BALMAIN, A [1 ]
KNOWLER, JT [1 ]
机构：
[1] BEATSON INST CANC RES,GLASGOW G61 1BD,SCOTLAND
来源：
EUROPEAN JOURNAL OF BIOCHEMISTRY | 1979年 / 100卷 / 01期
关键词：
D O I：
10.1111/j.1432-1033.1979.tb02037.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mRNA population of immature rat uteri, responding to different lengths of oestradiol‐induced differentiation, have been compared by the technique of DNA hybridization with heterogeneous RNA. Over the first 4 h of hormone induction there are continuing qualitative and quantitative changes in the poly(A)‐containing mRNA such that, by 4 h after oestradiol administration, the population bears little resemblance to that of the unstimulated animal. Between 2 h and 4 h after oestradiol administration, the most striking changes appear to be in sequences of intermediate abundance. The possible significance of these findings is discussed. Copyright © 1979, Wiley Blackwell. All rights reserved
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页码：95 / 100
页数：6
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