SYNTHESIS AND BIOLOGIC DISTRIBUTION OF MERCAPTO DERIVATIVES OF PALMITIC ACID

被引：13
作者：
LIVNI, E
DAVIS, MA
WARNER, VD
机构：
[1] NORTHWESTERN UNIV,COLL PHARM & ALLIED HLTH PROFESS,DEPT MED CHEM & PHARMACOL,CHICAGO,IL 60611
[2] HARVARD UNIV,SCH MED,DEPT RADIOL,JOINT PROGRAM NUCL MED,BOSTON,MA 02115
[3] CHILDRENS HOSP MED CTR,BOSTON,MA 02115
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 05期
关键词：
D O I：
10.1021/jm00191a024
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Mercapto derivatives of palmitic acid are capable of binding 99mTc. Based on the hypothesis that 99mTc-labeled palmitic acid derivatives would behave biologically like palmitic acid and thus could be used as myocardial imaging agents, three mercaptopalmitic acid derivatives have been prepared. The synthesis of 2-mercaptopalmitic acid, 2-mercapto-1, 16-hexadecanedioic acid, and 16-mercaptopalmitic acid was accomplished by reaction of the corresponding bromo compound with thiourea. The 35S-labeled compounds and [16-14C]palmitic acid were evaluated in rats with a heat-inflicted myocardial infarction to study the effect of the introduction of the mercapto group. The organ distribution of 2-[35S]mercaptopalmitic acid was most similar to that of [16-14C]palmitic acid. © 1979, American Chemical Society. All rights reserved.
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页码：580 / 583
页数：4
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