MODULATION OF TRANSCRIPTION IN RAT-LIVER NUCLEI INVITRO BY A DIOL EPOXIDE OF BENZO[A]PYRENE

被引：2
|
作者：
SHAH, GM [1 ]
BHATTACHARYA, RK [1 ]
机构：
[1] BHABHA ATOM RES CTR,DIV BIOCHEM,BOMBAY 400085,INDIA
来源：
JOURNAL OF BIOCHEMICAL TOXICOLOGY | 1992年 / 7卷 / 01期
关键词：
7-BETA,8-ALPHA-DIHYDROXY-9-ALPHA-10-ALPHA-EPOXY-7,8,9,10-TETRAHYDROBENZO[A]PYRENE; NUCLEAR TRANSCRIPTION; CHROMATIN; RNA POLYMERASES;
D O I：
10.1002/jbt.2570070104
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Treatment of isolated rat liver nuclei with 7-beta,8-alpha-dihydroxy-9-alpha, l0-alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, the ultimate carcinogenic metabolite of benzo[a]pyrene, resulted in inhibition of transcription as measured by radioactive precursor incorporation into RNA. The mechanism of inhibition as analyzed by use of different types of inhibitors suggested that the carcinogen acted on both the major components of transcription machinery, that is, the template chromatin and the enzyme RNA polymerases. This action correlates well with the observations made after administration of benzo[a]pyrene to rats.
引用
收藏
页码：13 / 17
页数：5
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