BETA-A4 AMYLOID PROTEIN DEPOSITION IN BRAIN AFTER HEAD TRAUMA

被引：394

作者：

ROBERTS, GW ^{[1
]}

GENTLEMAN, SM ^{[1
]}

LYNCH, A ^{[1
]}

GRAHAM, DI ^{[1
]}

机构：

[1] SO GEN HOSP,INST NEUROL SCI,DEPT NEUROPATHOL,GLASGOW G51 4TF,SCOTLAND

来源：

LANCET | 1991年 / 338卷 / 8780期

关键词：

D O I：

10.1016/0140-6736(91)92724-G

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Previous reports have suggested that both repetitive head trauma and a single injury can be associated with the presence of diffuse beta-A4 amyloid protein plaques in long-term survivors. We have studied sixteen patients (aged 10-63 years) who sustained head injury and survived for only 6-18 days. Immunostaining with an antibody to beta-A4 amyloid showed extensive deposits of the protein in the cortex in six of the sixteen patients (38%). Thus, severe head injury can trigger beta-A4 deposition in the brain within days.

引用

页码：1422 / 1423

页数：2

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