VITAMIN-K-DEPENDENT CARBOXYLASE - STRUCTURAL REQUIREMENTS FOR PROPEPTIDE ACTIVATION

被引：9

作者：

CHEUNG, A

SUTTIE, JW

BERNATOWICZ, M

机构：

[1] UNIV WISCONSIN,COLL AGR & LIFE SCI,DEPT BIOCHEM,MADISON,WI 53706

[2] MILLIGEN BIOSEARCH,BURLINGTON,MA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1039卷 / 01期

关键词：

Propeptide; Vitamin K; γ-Carboxyglutamic acid;

D O I：

10.1016/0167-4838(90)90230-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The activity of the rat liver vitamin K-dependent γ-glutamyl carboxylase has been shown to be stimulated by the presence of the free amino terminal 'propeptide' region of the primary gene product of its normal protein substrates. A series of analogs of the human factor X propeptide have been utilized to demonstrate the structure/function relationships important in these interactions. © 1990.

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页码：90 / 93

页数：4

相关论文

共 20 条

[1] VITAMIN-K-DEPENDENT CARBOXYLASE - INFLUENCE OF THE PROPEPTIDE REGION ON ENZYME-ACTIVITY [J].

CHEUNG, A ;

ENGELKE, JA ;

SANDERS, C ;

SUTTIE, JW .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1989, 274 (02) :574-581

[2]

Cleland W W, 1979, Methods Enzymol, V63, P103

[3]

DAVIE EW, 1987, HEMOSTASIS THROMBOSI, P242

[4] PROPEPTIDE OF HUMAN PROTEIN-C IS NECESSARY FOR GAMMA-CARBOXYLATION [J].

FOSTER, DC ;

RUDINSKI, MS ;

SCHACH, BG ;

BERKNER, KL ;

KUMAR, AA ;

HAGEN, FS ;

SPRECHER, CA ;

INSLEY, MY ;

DAVIE, EW .

BIOCHEMISTRY, 1987, 26 (22) :7003-7011

[5] THE MOLECULAR-BASIS OF BLOOD-COAGULATION [J].

FURIE, B ;

FURIE, BC .

CELL, 1988, 53 (04) :505-518

[6] VITAMIN-K-DEPENDENT CARBOXYLASE - PARTIAL-PURIFICATION OF THE ENZYME BY ANTIBODY-AFFINITY TECHNIQUES [J].

HARBECK, MC ;

CHEUNG, AY ;

SUTTIE, JW .

THROMBOSIS RESEARCH, 1989, 56 (02) :317-323

[7]

HUBBARD BR, 1989, J BIOL CHEM, V264, P14145

[8] VITAMIN-K-DEPENDENT CARBOXYLASE - AFFINITY PURIFICATION FROM BOVINE LIVER BY USING A SYNTHETIC PROPEPTIDE CONTAINING THE GAMMA-CARBOXYLATION RECOGNITION SITE [J].

HUBBARD, BR ;

ULRICH, MMW ;

JACOBS, M ;

VERMEER, C ;

WALSH, C ;

FURIE, B ;

FURIE, BC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (18) :6893-6897

[9] RECOGNITION SITE DIRECTING VITAMIN-K-DEPENDENT GAMMA-CARBOXYLATION RESIDES ON THE PROPEPTIDE OF FACTOR-IX [J].

JORGENSEN, MJ ;

CANTOR, AB ;

FURIE, BC ;

BROWN, CL ;

SHOEMAKER, CB ;

FURIE, B .

CELL, 1987, 48 (02) :185-191

[10]

KNOBLOCH JE, 1987, J BIOL CHEM, V262, P15334