INVIVO ANTITUMOR-ACTIVITY OF ILMOFOSINE

被引：25
作者：
HERRMANN, DBJ
PAHLKE, W
OPITZ, HG
BICKER, U
机构：
[1] Boehringer Mannheim GmbH, Department of Immunopharmacology, 6800 Mannheim 31
来源：
CANCER TREATMENT REVIEWS | 1990年 / 17卷 / 2-3期
关键词：
D O I：
10.1016/0305-7372(90)90055-K
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ilmofosine is a cytostatic/cytotoxic thioether phospholipid derivative. The in vivo anti- tumour activity of this compound was investigated in a methylcholanthrene (MethA)induced fibrosarcoma and in the 3Lewis-lung carcinoma systems, respectively. Ilmofosine showed antineoplastic and antimetastatic properties at oral doses ranging from 0.625 to 40 mg/kg/day. Combination of Ilmofosine (p.o.) together with either cyclophosphamide (p.o.) or cis-DDP (i.v.) resulted in synergistic effects in vivo. These results demonstrate the in vivo antitumour activity of Ilmofosine in two tumour systems. The data indicate that direct cytostatic/cytotoxic effects of Ilmofosine are mainly responsible for its antitumour activity in vivo and which are increased by other cytotoxics. © 1990.
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页码：247 / 252
页数：6
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