HYPOTENSIVE AND RENOVASCULAR ACTIONS OF 6-KETO-PROSTAGLANDIN E1, A METABOLITE OF PROSTACYCLIN

被引：85

作者：

QUILLEY, CP

WONG, PYK

MCGIFF, JC

机构：

[1] Department of Pharmacology, University of Tennessee Center for the Health Sciences, Memphis

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 57卷 / 2-3期

关键词：

6-Keto-prostaglandin E[!sub]1[!/sub; Blood pressure; Prostacyclin; Rat; Renovascular resistance;

D O I：

10.1016/0014-2999(79)90378-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Either intra-aortic or intravenous injections of a stable prostaglandin metabolite, 6-keto-prostaglandin E1 (6-keto-PGE1), caused similar dose-dependent falls in blood pressure and reductions in renovascular resistance in the anesthetized rat. The threshold dose was 0.3 μg/kg. A maximum hypotensive effect occurred at 10 μg/kg, but renal blood flow was further reduced by a dose of 30 μg/kg. 6-keto-PGE1, like prostacyclin, could be a circulating hormone. © 1979.

引用

页码：273 / 276

页数：4

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