DRUG-INDUCED RELEASE OF CATECHOLAMINES SOLUBLE PROTEIN AND CHROMOGRANIN A FROM ISOLATED BOVINE ADRENAL GLAND

被引：21
作者：
SCHNEIDER, FH
机构：
[1] Department of Pharmacology, University of Oxford, Oxford, England
来源：
BIOCHEMICAL PHARMACOLOGY | 1969年 / 18卷 / 01期
基金：
英国医学研究理事会; 美国国家科学基金会;
关键词：
D O I：
10.1016/0006-2952(69)90014-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Catecholamines, soluble protein, chromogranin A and lactate dehydrogenase (LDH) activity were measured in perfusates from isolated bovine adrenal glands after stimulation of the glands with carbachol, phenylethylamine and ethylenediamine. The ratio of catecholamine to chromogranin A secreted was similar in each case, whereas the amount of soluble protein secreted depended upon the stimulant used. LDH activity of perfusates was unchanged after stimulation with carbachol. The effect of phenylethylamine on LDH secretion was variable. Secretion by carbachol was completely abolished and secretion by phenylethylamine was partially inhibited in calcium-free solution. These results support the hypothesis that, as a result of stimulation with carbachol, catecholamines are released from the adrenal gland by a process of exocytosis. © 1969.
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页码：101 / +
页数：1
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