FREQUENCY AND MECHANISM OF RESISTANCE TO ANTIBACTERIAL ACTION OF ZM-240401, (6S)-6-FLUORO-SHIKIMIC ACID

被引：18

作者：

EWART, CDC ^{[1
]}

JUDE, DA ^{[1
]}

THAIN, JL ^{[1
]}

NICHOLS, WW ^{[1
]}

机构：

[1] ZENECA PHARMACEUT, DEPT INFECT RES, MACCLESFIELD SK10 4TG, CHESHIRE, ENGLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 01期

关键词：

D O I：

10.1128/AAC.39.1.87

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Spontaneous resistance to (6S)-6-fluoro-shikimic acid arose in Escherichia coli and other enterobacteria at high frequencies, between 10(-5) and 10(-4). Two resistant variants of E. coli were tested for their susceptibilities to the diastereomeric compound, (6R)-6-fluoro-shikimate, and both of them had become resistant to this compound as well. (6S)-6-Fluoro-shikimate-resistant variants of E. coli generally failed to transport [C-14] shikimate. In E. coli K-12, (6S)-6-fluoro-shikimate resistance cotransduced with his at the same frequency as shiA, a gene locus that governs shikimate transport phenotypes. We propose that the loss of susceptibility to (6S)6-fluoro-shikimic acid in spontaneous resistant variants is due to the loss of activity of the transport system by which it enters the bacterial cytoplasm.

引用

页码：87 / 93

页数：7

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