PHOTOCHEMISTRY OF SUBSTITUTED PROPIOPHENONES - AN INTERESTING ALPHA-SUBSTITUENTS AND ARYL-SUBSTITUENTS EFFECT ON THEIR PHOTOBEHAVIOR

Photochemistry of different alpha-substituted and phenyl-substituted propiophenones in methanol is investigated with a view to delineate the substituent effect with a special reference to their rearrangement to alpha-arylpropanoic acids, an important class of nonsteroidal antiinflammatory agents. The results thus obtained bringsforth an important element of their reactivity profile i.e. the alpha-chloro-substituent in combination with nuclear alkyl substituents (para > meta) favours 1,2-arylmigration leading to the synthetically useful reaction for alpha-arylpropanoic acids.