ARE THE ASSOCIATIONS BETWEEN ALZHEIMERS-DISEASE AND POLYMORPHISMS IN THE APOLIPOPROTEIN-E AND THE APOLIPOPROTEIN-CII GENES DUE TO LINKAGE DISEQUILIBRIUM

被引：43

作者：

TSUDA, T

LOPEZ, R

ROGAEVA, EA

FREEDMAN, M

ROGAEV, E

DRACHMAN, D

POLLEN, D

HAINES, J

LIANG, Y

MCLACHLAN, DRC

DUARA, R

STGEORGEHYSLOP, P

机构：

[1] UNIV TORONTO,DEPT MED,DIV NEUROL,TORONTO M5S 1A8,ON,CANADA

[2] UNIV TORONTO,CTR RES NEURODEGENERAT DIS,TORONTO M5S 1A8,ON,CANADA

[3] UNIV MIAMI,MT SINAI MED CTR,WEIN CTR ALZHEIMER DIS,MIAMI BEACH,FL 33140

[4] BAYCREST CTR GERIATR CARE,BEHAV NEUROL PROGRAM,TORONTO,ON,CANADA

[5] BAYCREST CTR GERIATR CARE,ROTMAN RES INST,TORONTO,ON,CANADA

[6] UNIV MASSACHUSETTS,MED CTR,DEPT NEUROL,WORCESTER,MA 01655

[7] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,MOLEC NEUROGENET UNIT,BOSTON,MA

[8] RUSSIAN ACAD MED SCI,NATL RES CTR MENTAL HLTH,MOSCOW,RUSSIA

[9] MT SINAI HOSP,DEPT MED NEUROL,TORONTO M5G 1X5,ON,CANADA

来源：

ANNALS OF NEUROLOGY | 1994年 / 36卷 / 01期

关键词：

D O I：

10.1002/ana.410360118

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Allele frequencies for polymorphisms in the apolipoprotein E and the apolipoprotein CII genes were determined in subjects of Ashkenazi Jewish origin with late-onset Alzheimer's disease and in unaffected control subjects from the same ethnic group. A significant association was observed between late-onset Alzheimer's disease and the epsilon 4 (112(Cys-->Arg)) allele of apolipoprotein E; however, no association was detected with apolipoprotein CII. These results suggest that the association with epsilon 4 is probably not due to linkage disequilibrium.

引用

页码：97 / 100

页数：4

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