ROLE OF PROTEASE INHIBITION IN MYOCARDIAL PRESERVATION FOLLOWING ISCHEMIA AND REPERFUSION

被引：0
作者：
GUREVITCH, J [1 ]
PAZ, Y [1 ]
BARAK, J [1 ]
MATSA, M [1 ]
KRAMER, A [1 ]
PEVNI, D [1 ]
HOCHHAUSER, E [1 ]
YAKIREVICH, V [1 ]
机构：
[1] ICHILOV HOSP,DEPT THORAC & CARDIOVASC SURG,IL-64239 TEL AVIV,ISRAEL
来源：
JOURNAL OF CARDIOVASCULAR SURGERY | 1994年 / 35卷 / 06期
关键词：
APROTININ; MYOCARDIAL REPERFUSION; ISCHEMIA;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aprotinin, a naturally occurring protease inhibitor, in concentrations of 10(6) KIU/L was found to have no effect on myocardial performance in normally perfused isolated rat hearts, before ischemia. Given during the preischemic period, the drug had a significant protective effect on the reperfused hearts, following cardioplegic ischemia: better contractility upon reperfusion (p < 0.011), faster decline of the ischemic contracture, higher coronary flow (p < 0,025), lower AV-difference (p < 0.05), and lower CPK levels (p < 0.01).
引用
收藏
页码：95 / 98
页数：4
相关论文
共 50 条
  • [41] Protective approaches against myocardial ischemia reperfusion injury
    Li, Xianchi
    Liu, Min
    Sun, Rongrong
    Zeng, Yi
    Chen, Shuang
    Zhang, Peiying
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2016, 12 (06) : 3823 - 3829
  • [42] Influence of myocardial ischemia and reperfusion on β-adrenoceptor subtype expression
    Bartels, LA
    Clifton, GD
    Szabo, TS
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1998, 31 (04) : 484 - 487
  • [43] Status of myocardial antioxidants in ischemia-reperfusion injury
    Dhalla, NS
    Elmoselhi, AB
    Hata, T
    Makino, N
    CARDIOVASCULAR RESEARCH, 2000, 47 (03) : 446 - 456
  • [44] T1 measurements in a rat model of acute myocardial ischemia/reperfusion
    Darach O h-Ici
    Sarah Jeuthe
    Titus Kuehne
    Felix Berger
    Sebastian Kozerke
    Daniel Messroghli
    Journal of Cardiovascular Magnetic Resonance, 18 (Suppl 1)
  • [45] Effects of Nitrate Intake on Myocardial Ischemia-Reperfusion Injury in Diabetic Rats
    Jeddi, Sajad
    Khalifi, Saeedeh
    Ghanbari, Mahboubeh
    Bageripour, Fatemeh
    Ghasemi, Asghar
    ARQUIVOS BRASILEIROS DE CARDIOLOGIA, 2016, 107 (04) : 339 - 347
  • [46] TNFα in atherosclerosis, myocardial ischemia/reperfusion and heart failure
    Kleinbongard, Petra
    Heusch, Gerd
    Schulz, Rainer
    PHARMACOLOGY & THERAPEUTICS, 2010, 127 (03) : 295 - 314
  • [47] Antithrombin is protective against myocardial ischemia and reperfusion injury
    Wang, J.
    Wang, Y.
    Wang, J.
    Gao, J.
    Tong, C.
    Manithody, C.
    Li, J.
    Rezaie, A. R.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2013, 11 (06) : 1020 - 1028
  • [48] The Hedgehog morphogen in myocardial ischemia-reperfusion injury
    Bijlsma, Maarten F.
    Spek, C. Arnold
    EXPERIMENTAL BIOLOGY AND MEDICINE, 2010, 235 (04) : 447 - 454
  • [49] Experimental study on the effects of aprotinin on myocardial ischemia and reperfusion
    Cheng Guangming
    Lan Hongjun
    Sun Zongquan
    Zhang Kailun
    Du Xinling
    Current Medical Science, 1997, 17 (1) : 36 - 39
  • [50] Effects of tramadol on myocardial ischemia-reperfusion injury
    Bilir, Ayten
    Erkasap, Nilufer
    Koken, Tulay
    Gulec, Sacit
    Kaygisiz, Ziya
    Tanriverdi, Belkis
    Kurt, Imran
    SCANDINAVIAN CARDIOVASCULAR JOURNAL, 2007, 41 (04) : 242 - 247
12345