ROLE OF PROTEASE INHIBITION IN MYOCARDIAL PRESERVATION FOLLOWING ISCHEMIA AND REPERFUSION

被引：0
作者：
GUREVITCH, J [1 ]
PAZ, Y [1 ]
BARAK, J [1 ]
MATSA, M [1 ]
KRAMER, A [1 ]
PEVNI, D [1 ]
HOCHHAUSER, E [1 ]
YAKIREVICH, V [1 ]
机构：
[1] ICHILOV HOSP,DEPT THORAC & CARDIOVASC SURG,IL-64239 TEL AVIV,ISRAEL
来源：
JOURNAL OF CARDIOVASCULAR SURGERY | 1994年 / 35卷 / 06期
关键词：
APROTININ; MYOCARDIAL REPERFUSION; ISCHEMIA;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aprotinin, a naturally occurring protease inhibitor, in concentrations of 10(6) KIU/L was found to have no effect on myocardial performance in normally perfused isolated rat hearts, before ischemia. Given during the preischemic period, the drug had a significant protective effect on the reperfused hearts, following cardioplegic ischemia: better contractility upon reperfusion (p < 0.011), faster decline of the ischemic contracture, higher coronary flow (p < 0,025), lower AV-difference (p < 0.05), and lower CPK levels (p < 0.01).
引用
收藏
页码：95 / 98
页数：4
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