DIETARY-FAT PROMOTES MAMMARY TUMORIGENESIS IN MMTV V-HA-RAS TRANSGENIC MICE

被引：21

作者：

DEWILLE, JW

WADDELL, K

STEINMEYER, C

FARMER, SJ

机构：

[1] The Ohio State University, The Ohio Sate University Biochemistry Program, Department of Veterinary Pathobiology, Columbus, OH 43210-1093

来源：

CANCER LETTERS | 1993年 / 69卷 / 01期

关键词：

DIETARY FAT; TRANSGENIC MICE; ONCOGENE AMPLIFICATION; HYPOMETHYLATION;

D O I：

10.1016/0304-3835(93)90033-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The purpose of this study was to investigate the influence of dietary fat on mammary tumorigenesis in MMTV/v-Ha-ras transgenic mice. Female MMTV/v-Ha-ras transgenics were fed diets providing 0, 5 or 25% of calories from corn oil (CO). The mammary tumor incidence was 7% (0% CO), 36% (5% CO) and 52% (25% CO). Ras mRNA levels were increased in mammary tumors in the 25% CO group. The ras transgene was hypomethylated in mammary tumors, but not in liver or non-transformed mammary tissue. Mammary tumors expressed apolipoprotein E mRNA. Alterations in gene structure and expression in transgenic mice may suggest mechanisms by which dietary fat promotes mammary tumors.

引用

页码：59 / 66

页数：8

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