CHITOSAN AS A NOVEL NASAL DELIVERY SYSTEM FOR PEPTIDE DRUGS

被引：531
|
作者：
ILLUM, L
FARRAJ, NF
DAVIS, SS
机构：
[1] Albert Einstein Centre, DanBioSyst UK Ltd., Nottingham, NG7 2TN, Highfields Science Park
来源：
PHARMACEUTICAL RESEARCH | 1994年 / 11卷 / 08期
关键词：
CHITOSAN; NASAL DELIVERY; INSULIN; SHEEP;
D O I：
10.1023/A:1018901302450
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A nasal solution formulation of the cationic material chitosan was shown to greatly enhance the absorption of insulin across the nasal mucosa of rat and sheep. The absorption promoting effect was concentration dependent with the optimal efficacy obtained for concentrations higher than 0.2% and 0.5% in rats and sheep, respectively. The absorption promoting effect was reversible with time in a ''pulse-chase'' study. Histological examination of the nasal mucosa of rats exposed to a chitosan solution for 60 minutes showed little change.
引用
收藏
页码：1186 / 1189
页数：4
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