NITRIC-OXIDE IS THE ENDOGENOUS NEUROTRANSMITTER OF BRONCHODILATOR NERVES IN HUMANS

被引：336

作者：

BELVISI, MG ^{[1
]}

STRETTON, CD ^{[1
]}

YACOUB, M ^{[1
]}

BARNES, PJ ^{[1
]}

机构：

[1] NATL HEART & LUNG INST, DEPT CARDIOTHORAC SURG, LONDON SW3 6LY, ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 210卷 / 02期

关键词：

NITRIC OXIDE (NO); NONADRENERGIC NONCHOLINERGIC INHIBITORY (I-NANC) NERVES; TRACHEA (HUMAN);

D O I：

10.1016/0014-2999(92)90676-U

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In human airways, there is a prominent neural bronchodilator mechanism which is non-adrenergic. In human tracheal segments, we have demonstrated that this response is mediated entirely by nitric oxide (NO), since an inhibitor of NO synthesis, L-N(G)-nitroarginine methyl ester (L-NAME) (10(-1) M) abolishes this neural response. Identification of the neurotransmitter of this bronchodilator pathway may now make it possible to study its role in physiological control of airway calibre and in airway disease.

引用

页码：221 / 222

页数：2

共 5 条

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