ACETOGENINS OF THE ANNONACEAE .20. BIOACTIVE ACETOGENINS FROM SEEDS OF ANNONA-CHERIMOLIA

被引：48
|
作者：
CORTES, D
MYINT, SH
DUPONT, B
DAVOUST, D
机构：
[1] UNIV ROUEN, CHIM ORGAN LAB, SERV RMN, CNRS, URA 464, F-76134 MONT ST AIGNAN, FRANCE
[2] UNIV PARIS 11, FAC PHARM, CNRS, PHARMACOGNOSIE LAB, F-92290 CHATENAY MALABRY, FRANCE
来源：
PHYTOCHEMISTRY | 1993年 / 32卷 / 06期
关键词：
ANNONA-CHERIMOLIA; ANNONACEAE; ACETOGENINS; TETRAHYDROFURAN GAMMA-LACTONES; CYTOTOXICITY; ANTIPARASITIC ACTIVITY;
D O I：
10.1016/0031-9422(93)85162-K
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new cytotoxic, nonadjacent bis-tetrahydrofuran acetogenins, cherimolin-2 and almunequin, have been isolated from the bioactive methanolic extract of Annona cherimolia seeds. In addition to these new compounds, the structure of the known acetogenins, cherimolin-1, laherradurin and otivarin (ex-dihydrocherimolin), are here revised. The structures were established by means of one- and two-dimensional NMR experiments. All compounds exhibited potent cytotoxic and antiparasitic activities.
引用
收藏
页码：1475 / 1482
页数：8
相关论文
共 50 条
  • [21] ALKALOIDS FROM ANNONA-CHERIMOLIA LEAVES
    VILLAR, A
    MARES, M
    RIOS, JL
    CORTES, D
    JOURNAL OF NATURAL PRODUCTS, 1985, 48 (01): : 151 - 152
  • [22] Annonaceous acetogenins: Precursors from the seeds of Annona squamosa
    Ndob, Idensi Bajin Ba
    Champy, Pierre
    Gleye, Christophe
    Lewin, Guy
    Akendengue, Blandine
    PHYTOCHEMISTRY LETTERS, 2009, 2 (02) : 72 - 76
  • [23] ANNONACEOUS ACETOGENINS FROM THE SEEDS OF ANNONA-SQUAMOSA - ADJACENT BIS-TETRAHYDROFURANIC ACETOGENINS
    SAHAI, M
    SINGH, S
    SINGH, M
    GUPTA, YK
    AKASHI, S
    YUJI, R
    HIRAYAMA, K
    ASAKI, H
    ARAYA, H
    HARA, N
    EGUCHI, T
    KAKINUMA, K
    FUJIMOTO, Y
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1994, 42 (06) : 1163 - 1174
  • [24] Monotetrahydrofuran annonaceous acetogenins from the seeds of Annona squamosa
    Chen, Yong
    Chen, Jiang-wei
    Li, Xiang
    PHYTOCHEMISTRY LETTERS, 2012, 5 (01) : 33 - 36
  • [25] ACETOGENINS OF THE ANNONACEAE .21. BIS-TETRAHYDROFURAN ACETOGENINS FROM ANNONACEAE
    CORTES, D
    FIGADERE, B
    CAVE, A
    PHYTOCHEMISTRY, 1993, 32 (06) : 1467 - 1473
  • [26] ALKALOIDS FROM ANNONA-CHERIMOLIA SEED
    DELFRESNO, AV
    CANAVATE, JLR
    JOURNAL OF NATURAL PRODUCTS, 1983, 46 (03): : 438 - 438
  • [27] Annosenegalin and annogalene: Two cytotoxic mono-tetrahydrofuran acetogenins from Annona senegalensis and Annona cherimolia
    Sahpaz, S
    Gonzalez, MC
    Hocquemiller, R
    ZafraPolo, MC
    Cortes, D
    PHYTOCHEMISTRY, 1996, 42 (01) : 103 - 107
  • [28] Genotoxic and Cytotoxic Effects Produced by Acetogenins Obtained from Annona cherimolia MILL.
    Garcia-Aguirre, Karol Karla
    Zepeda-Vallejo, Luis Gerardo
    Ramon-Gallegos, Eva
    Alvarez-Gonzalez, Isela
    Madrigal-Bujaidar, Eduardo
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2008, 31 (12) : 2346 - 2349
  • [29] Additional bioactive annonaceous acetogenins from Asimina triloba (Annonaceae)
    He, K
    Zhao, GX
    Shi, G
    Zeng, L
    Chao, JF
    McLaughlin, JL
    BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5 (03) : 501 - 506
  • [30] Six cytotoxic annonaceous acetogenins from Annona squamosa seeds
    Chen, Yong
    Chen, Jian-wei
    Wang, Yu
    Xu, Sha-sha
    Li, Xiang
    FOOD CHEMISTRY, 2012, 135 (03) : 960 - 966
12345