ACETOGENINS OF THE ANNONACEAE .20. BIOACTIVE ACETOGENINS FROM SEEDS OF ANNONA-CHERIMOLIA

被引：48
作者：
CORTES, D
MYINT, SH
DUPONT, B
DAVOUST, D
机构：
[1] UNIV ROUEN, CHIM ORGAN LAB, SERV RMN, CNRS, URA 464, F-76134 MONT ST AIGNAN, FRANCE
[2] UNIV PARIS 11, FAC PHARM, CNRS, PHARMACOGNOSIE LAB, F-92290 CHATENAY MALABRY, FRANCE
来源：
PHYTOCHEMISTRY | 1993年 / 32卷 / 06期
关键词：
ANNONA-CHERIMOLIA; ANNONACEAE; ACETOGENINS; TETRAHYDROFURAN GAMMA-LACTONES; CYTOTOXICITY; ANTIPARASITIC ACTIVITY;
D O I：
10.1016/0031-9422(93)85162-K
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new cytotoxic, nonadjacent bis-tetrahydrofuran acetogenins, cherimolin-2 and almunequin, have been isolated from the bioactive methanolic extract of Annona cherimolia seeds. In addition to these new compounds, the structure of the known acetogenins, cherimolin-1, laherradurin and otivarin (ex-dihydrocherimolin), are here revised. The structures were established by means of one- and two-dimensional NMR experiments. All compounds exhibited potent cytotoxic and antiparasitic activities.
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页码：1475 / 1482
页数：8
相关论文
共 20 条
  • [11] STEREOCONTROLLED SYNTHESIS OF 2,5-LINKED MONOTETRAHYDROFURAN UNITS OF ACETOGENINS
    HARMANGE, JC
    FIGADERE, B
    CAVE, A
    [J]. TETRAHEDRON LETTERS, 1992, 33 (39) : 5749 - 5752
  • [12] BULLATALICIN, A NOVEL BIOACTIVE ACETOGENIN FROM ANNONA-BULLATA (ANNONACEAE)
    HUI, YH
    RUPPRECHT, JK
    ANDERSON, JE
    LIU, YM
    SMITH, DL
    CHANG, CJ
    MCLAUGHLIN, JL
    [J]. TETRAHEDRON, 1989, 45 (22) : 6941 - 6948
  • [13] DESACETYLUVARICIN FROM UVARIA-ACCUMINATA, CONFIGURATION OF UVARICIN AT C-36
    JOLAD, SD
    HOFFMANN, JJ
    COLE, JR
    BARRY, CE
    BATES, RB
    LINZ, GS
    KONIG, WA
    [J]. JOURNAL OF NATURAL PRODUCTS, 1985, 48 (04): : 644 - 645
  • [14] PRECISE C-13 NMR MULTIPLICITY DETERMINATION
    LECOCQ, C
    LALLEMAND, JY
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1981, (04) : 150 - 152
  • [15] SYLVATICIN - A NEW CYTOTOXIC AND INSECTICIDAL ACETOGENIN FROM ROLLINIA-SYLVATICA (ANNONACEAE)
    MIKOLAJCZAK, KJ
    MADRIGAL, RV
    RUPPRECHT, JK
    HUI, YH
    LIU, YM
    SMITH, DL
    MCLAUGHLIN, JL
    [J]. EXPERIENTIA, 1990, 46 (03): : 324 - 327
  • [16] MYINT SH, 1990, HETEROCYCLES, V31, P861
  • [17] MYINT SH, 1991, PHYTOCHEMISTRY, V30, P3335, DOI 10.1016/0031-9422(91)83204-X
  • [18] ACETOGENINS, APORPHINOIDS, AND AZAANTHRAQUINONE FROM ANNONA-CHERIMOLIA SEEDS
    RIOS, JL
    CORTES, D
    VALVERDE, S
    [J]. PLANTA MEDICA, 1989, (03) : 321 - 323
  • [19] RUPPRECHT JK, 1986, HETEROCYCLES, V24, P1197
  • [20] ANNONACEOUS ACETOGENINS - A REVIEW
    RUPPRECHT, JK
    HUI, YH
    MCLAUGHLIN, JL
    [J]. JOURNAL OF NATURAL PRODUCTS, 1990, 53 (02): : 237 - 278
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