ACETOGENINS OF THE ANNONACEAE .20. BIOACTIVE ACETOGENINS FROM SEEDS OF ANNONA-CHERIMOLIA

被引：48
作者：
CORTES, D
MYINT, SH
DUPONT, B
DAVOUST, D
机构：
[1] UNIV ROUEN, CHIM ORGAN LAB, SERV RMN, CNRS, URA 464, F-76134 MONT ST AIGNAN, FRANCE
[2] UNIV PARIS 11, FAC PHARM, CNRS, PHARMACOGNOSIE LAB, F-92290 CHATENAY MALABRY, FRANCE
来源：
PHYTOCHEMISTRY | 1993年 / 32卷 / 06期
关键词：
ANNONA-CHERIMOLIA; ANNONACEAE; ACETOGENINS; TETRAHYDROFURAN GAMMA-LACTONES; CYTOTOXICITY; ANTIPARASITIC ACTIVITY;
D O I：
10.1016/0031-9422(93)85162-K
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new cytotoxic, nonadjacent bis-tetrahydrofuran acetogenins, cherimolin-2 and almunequin, have been isolated from the bioactive methanolic extract of Annona cherimolia seeds. In addition to these new compounds, the structure of the known acetogenins, cherimolin-1, laherradurin and otivarin (ex-dihydrocherimolin), are here revised. The structures were established by means of one- and two-dimensional NMR experiments. All compounds exhibited potent cytotoxic and antiparasitic activities.
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页码：1475 / 1482
页数：8
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