CONFIGURATIONAL ISOMERIZATION OF BILIRUBIN AND THE MECHANISM OF JAUNDICE PHOTOTHERAPY

被引：79

作者：

LIGHTNER, DA

WOOLDRIDGE, TA

MCDONAGH, AF

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,CTR LIVER,SAN FRANCISCO,CA 94143

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 86卷 / 02期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0006-291X(79)90857-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bilirubin-IXα and its dimethyl ester, which have the Z configuration at the meso bridge double bonds, undergo rapid and reversible photoisomerization on irradiation with visible light giving Z-E, E-Z and E-E isomers. At photoequilibrium [Z-Z] ≫ [E-Z] ≈ [Z-E] > [E-E]. The non-Z-Z isomers of bilirubin-IXα are less lipophilic and more polar than the natural Z-Z isomer. The reaction probably is important in vivo during phototherapy of neonatal jaundice and responsible for the biliary excretion of unconjugated pigment associated with it. © 1979.

引用

页码：235 / 243

页数：9

共 21 条

[1] STRUCTURE OF BILIRUBIN [J].