MEAN STEADY-STATE PLASMA-CONCENTRATIONS OF LABETALOL IN PATIENTS UNDERGOING ANTIHYPERTENSIVE THERAPY

被引：6

作者：

SANDERS, GL ^{[1
]}

ROUTLEDGE, PA ^{[1
]}

WARD, A ^{[1
]}

DAVIES, DM ^{[1
]}

RAWLINS, MD ^{[1
]}

机构：

[1] SHOTLEY BRIDGE GEN HOSP,CONSETT,DURHAM,ENGLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1979年 / 8卷

关键词：

D O I：

10.1111/j.1365-2125.1979.tb04772.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 Mean steady‐state plasma concentrations of labetalol (labetalol Css) in 17 hypertensive patients undergoing chronic treatment with this drug, have been examined in relation to dose, fall in BP, and beta‐ blockade. 2 A significant relationship (rs = 0.81, P less than 0.001) was observed between labetalol Css and daily dose. 3 No correlation was found between labetalol Css and antihypertensive response. 4 In thirteen patients, there seemed to be significant relationship between labetalol Css and beta‐blockade (rs = 0.72, P less than 0.005). In three patients, the degree of beta‐blockade was disproportionate to the drug concentration. 1979 The British Pharmacological Society

引用

页码：S153 / S155

页数：3

共 7 条

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[6] STEADY-STATE PLASMA CONCENTRATIONS OF ALPRENOLOL IN MAN [J].

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[7] LABETALOL, A CROSSOVER DOUBLE-BLIND CONTROLLED TRIAL [J].

SANDERS, GL ;

ROUTLEDGE, PA ;

RAO, JG ;

GALES, GM ;

DAVIES, DM ;

RAWLINS, MD .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1978, 14 (05) :301-304

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