H-1-NMR AND ELECTRONIC SPECTRAL PROPERTIES OF ANTICANCER TRIARYLETHENE DERIVATIVES

E/Z-Diastereoneric triarylethenes 1 (analogs of Tamoxifen 2 Or Of Clomiphene, 3) can be differentiated by H-1-NMR. Assignments are presented in agreement with literature data for similar structures. Precursor carbinols 6 with an asymmetric carbon atom have diastereotopic methylene protons in the di-(p-benzyloxy)-methyl group. Electronic absorption spectra indicate the presence of carbocations 21 obtained by ketone protonation, and 23 formed analogously from the alkene 1 or from the precursor carbinol. Charge-transfer complexes of triarylethanones 20 with aromatic solvents are crystalline and useful for separations. The visible absorption spectra of charge-transfer complexes between 20 and DDQ are described.